ZEPATIER is a prescription medicine used with or without ribavirin to treat chronic (long-lasting) hepatitis C (hep C) genotypes 1 or 4 infection in adults. See important information below including the risk of hepatitis B virus reactivation.

 

About
Hepatitis C

About
Hepatitis C

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Information about hepatitis C

If you or someone you love has been living with hep C, it's good to stay informed.

Know the facts:
What is hepatitis C?
 

Hep C is a disease that affects the liver. It is caused by infection with the hep C virus, which is spread through contact with the blood of an infected person.

Hep C is a disease that affects the liver. It is caused by infection with the hep C virus, which is spread through contact with the blood of an infected person.

For most people, hep C will become a chronic infection, which means that the virus stays in the body for many years. Chronic hep C can eventually lead to serious liver damage, liver failure, or liver cancer.

Many people with hep C don’t have symptoms or even know they are infected. With chronic hep C infection, liver damage can be unpredictable, advancing slowly in some people and quickly in others. When symptoms occur, it can sometimes be a sign of more serious liver damage.

What are the different types of hep C?
 

There are 6 different types of the hep C virus, called genotypes. Genotype 1 is the most common type of hep C. Another less common type is genotype 4. It is important for people with hep C to know their genotype because that can help your health care provider choose a treatment plan that is right for you.

There are 6 different types of the hep C virus, called genotypes. Genotype 1 is the most common type of hep C. Another less common type is genotype 4. It is important for people with hep C to know their genotype because that can help your health care provider choose a treatment plan that is right for you.

Who should get tested for hep C?
 

Some situations may put a person at higher risk for getting hep C. Talk to your health care provider today about getting tested if any of the following apply to you, even if you're not experiencing symptoms:

Some situations may put a person at higher risk for getting hep C. Talk to your health care provider today about getting tested if any of the following apply to you, even if you're not experiencing symptoms:

  • You were born between 1945 and 1965

  • You have used injection drugs now or in the past

  • You were treated for a blood-clotting problem before 1987

  • You received a blood transfusion or organ transplant before July 1992

  • You are on dialysis for severe kidney disease

  • You have abnormal liver tests or have liver disease

  • You have been stuck with a needle or other sharp object that exposed you to an infected person's blood (usually applies to health care or public safety workers)

  • You have HIV

Your next chapter could start with ZEPATIER® (elbasvir and grazoprevir)
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Important Safety Information

Before starting treatment with ZEPATIER® (elbasvir and grazoprevir), your health care provider will do blood tests to check for hepatitis B virus infection. If you have ever had hepatitis B virus infection, the hepatitis B virus could become active again during or after treatment of hep C virus infection with ZEPATIER. This is called hepatitis B virus reactivation, and it may cause serious liver problems including liver failure and death. Your health care provider will monitor you if you are at risk for hepatitis B virus reactivation during treatment and after you stop taking ZEPATIER.

Important Safety Information continued below

ZEPATIER is not for people with certain liver problems. Before taking ZEPATIER, tell your health care provider about all of your medical conditions, including if you have ever had hepatitis B virus infection or have liver problems other than hep C. Also tell your health care provider if you have ever taken any medicine for hep C, have HIV, or have had or are waiting for a liver transplant.

If you are nursing, pregnant, or trying to get pregnant, tell your health care provider. It is not known if ZEPATIER will harm your unborn baby or pass to your baby through breast milk. If you take ZEPATIER with ribavirin, be sure you read the Medication Guide for ribavirin, especially the important pregnancy, contraception, and infertility information.

Tell your health care provider about all of the medicines you take. ZEPATIER may affect how other medicines work, and other medicines may affect how ZEPATIER works. Some medicines cannot be taken with ZEPATIER. Your health care provider can tell you if it is safe to take ZEPATIER with other medicines.

ZEPATIER may cause increases in your liver-related blood tests, which could be a sign of serious liver problems. Your health care provider will do blood tests to check your liver before and during treatment with ZEPATIER. Tell your health care provider right away if you get any of the following symptoms or if they get worse during treatment with ZEPATIER: loss of appetite, nausea and vomiting, feeling tired or weak, yellowing of your skin or eyes, or color changes in your stool.

In clinical studies, common side effects of ZEPATIER included: feeling tired, headache, and nausea. When ZEPATIER was taken with ribavirin, common side effects also included low red blood cell counts (called anemia).

What is ZEPATIER?

ZEPATIER is a prescription medicine used to treat chronic (long-lasting) hepatitis C (hep C) genotypes 1 or 4 infection in adults. ZEPATIER may sometimes be given with another medicine called ribavirin.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

Before taking ZEPATIER® (elbasvir and grazoprevir), please read the accompanying Patient Information, including information about the risk of the hepatitis B virus (HBV) becoming active again in patients who have ever had HBV infection, and discuss it with your doctor. The Prescribing Information also is available.

Questions about ZEPATIER?
Call 844-ZEPATIER (844-937-2843)
for more information.

Important Safety Information continued below