ZEPATIER is a prescription medicine used with or without ribavirin to treat chronic (long-lasting) hepatitis C (hep C) genotypes 1 or 4 infection in adults. See important information below including the risk of hepatitis B virus reactivation.

 

Taking
ZEPATIER

Taking
ZEPATIER

Model

ZEPATIER. One pill. Once a day.

Most people will take ZEPATIER® (elbasvir and grazoprevir) for 12 weeks. Some people may take ZEPATIER plus another medicine called ribavirin for 12 or 16 weeks. ZEPATIER® (elbasvir and grazoprevir) is 1 pill, once a day

ZEPATIER® (elbasvir and grazoprevir) is 1 pill, once a dayMost people will take ZEPATIER® (elbasvir and grazoprevir) for 12 weeks. Some people may take ZEPATIER plus another medicine called ribavirin for 12 or 16 weeks.

Your specific treatment plan depends on your
hep C genotype, if you were treated for hep C in the past, and if there are certain rare changes to your hep C virus. Your health care provider will decide the treatment course that is right for you.

ZEPATIER is taken to clear the hep C virus from your body. Your health care provider may refer to this as sustained virologic response, or cure of your infection. "Clearing the virus" means the hep C virus cannot be measured in your blood at least 3 months after completing treatment.

Taking ZEPATIER the way it’s prescribed is important to the success of your treatment. To give yourself the best chance of clearing the hep C virus, follow the instructions below.

How do I take ZEPATIER?
ZEPATIER® (elbasvir and grazoprevir) package 

ZEPATIER comes in a package designed to help you track your medicine every day. Each package has 14 tablets, labeled by days of the week for 2 weeks.

ZEPATIER comes in a package designed to help you track your medicine every day. Each package has 14 tablets, labeled by days of the week for 2 weeks.

It is important to keep your pills in this package until you are ready to take your medicine.

 

Take one ZEPATIER tablet every day.
You can take ZEPATIER with or without food. It is helpful to take ZEPATIER at the same time each day. It is important not to miss or skip doses of ZEPATIER during treatment.

 

Take ZEPATIER exactly as your health care provider tells you to take it.
Do not stop taking ZEPATIER without first talking with your health care provider. If you take more than your prescribed dose, call your health care provider right away.

Take ZEPATIER exactly as your health care provider tells you to take it.
Do not stop taking ZEPATIER without first talking with your health care provider. If you take more than your prescribed dose, call your health care provider right away.

Be sure to tell your health care provider about all other medicines you take, to find out which medicines can be taken with ZEPATIER. This includes prescription and over-the-counter medicines, vitamins, and herbal supplements. ZEPATIER may affect the way that other medicines work, and other medicines may affect how ZEPATIER works. Some medicines cannot be taken with ZEPATIER.


Medicines that can be taken with ZEPATIER include:

  • Acid reducers, like Pepcid® or Protonix®

  • Antacids

  • Birth control pills

Your health care provider can tell you if it is safe to take ZEPATIER with other medicines.

Where should I
keep ZEPATIER?
ZEPATIER® (elbasvir and grazoprevir) package

Keep ZEPATIER in its original
blister package

until it's time to
take your daily pill.

 

Store ZEPATIER at
room temperature.

 

Keep ZEPATIER
(and all medicines)
out of the reach of children.

It's important to keep your ZEPATIER pills dry and protected from moisture.

Need tips for remembering
to take ZEPATIER?
 

Set an electronic or
written reminder.

 

Make taking your pill part of your daily routine (when you wake up in the morning or at meal time).

 

Keep your medicine package
where you can see it.

 
 

Ask a friend or family
member for a reminder.

 

Refill your prescription
with plenty of time before
your medicine runs out.

What if I forget to
take ZEPATIER?
  • Your ZEPATIER pill should be taken once each day. It is important that you do not miss or skip doses of ZEPATIER.

  • If you miss your daily dose of ZEPATIER, call your health care provider or pharmacist with any questions. Do not take 2 doses of ZEPATIER at the same time to make up for a missed dose.

Stay on top of your hep C treatment
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Important Safety Information

Before starting treatment with ZEPATIER® (elbasvir and grazoprevir), your health care provider will do blood tests to check for hepatitis B virus infection. If you have ever had hepatitis B virus infection, the hepatitis B virus could become active again during or after treatment of hep C virus infection with ZEPATIER. This is called hepatitis B virus reactivation, and it may cause serious liver problems including liver failure and death. Your health care provider will monitor you if you are at risk for hepatitis B virus reactivation during treatment and after you stop taking ZEPATIER.

Important Safety Information continued below

ZEPATIER is not for people with certain liver problems. Before taking ZEPATIER, tell your health care provider about all of your medical conditions, including if you have ever had hepatitis B virus infection or have liver problems other than hep C. Also tell your health care provider if you have ever taken any medicine for hep C, have HIV, or have had or are waiting for a liver transplant.

If you are nursing, pregnant, or trying to get pregnant, tell your health care provider. It is not known if ZEPATIER will harm your unborn baby or pass to your baby through breast milk. If you take ZEPATIER with ribavirin, be sure you read the Medication Guide for ribavirin, especially the important pregnancy, contraception, and infertility information.

Tell your health care provider about all of the medicines you take. ZEPATIER may affect how other medicines work, and other medicines may affect how ZEPATIER works. Some medicines cannot be taken with ZEPATIER. Your health care provider can tell you if it is safe to take ZEPATIER with other medicines.

ZEPATIER may cause increases in your liver-related blood tests, which could be a sign of serious liver problems. Your health care provider will do blood tests to check your liver before and during treatment with ZEPATIER. Tell your health care provider right away if you get any of the following symptoms or if they get worse during treatment with ZEPATIER: loss of appetite, nausea and vomiting, feeling tired or weak, yellowing of your skin or eyes, or color changes in your stool.

In clinical studies, common side effects of ZEPATIER included: feeling tired, headache, and nausea. When ZEPATIER was taken with ribavirin, common side effects also included low red blood cell counts (called anemia).

What is ZEPATIER?

ZEPATIER is a prescription medicine used to treat chronic (long-lasting) hepatitis C (hep C) genotypes 1 or 4 infection in adults. ZEPATIER may sometimes be given with another medicine called ribavirin.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch or call
1-800-FDA-1088.

Before taking ZEPATIER® (elbasvir and grazoprevir), please read the accompanying Patient Information, including information about the risk of the hepatitis B virus (HBV) becoming active again in patients who have ever had HBV infection, and discuss it with your doctor. The Prescribing Information also is available.

Questions about ZEPATIER?
Call 844-ZEPATIER (844-937-2843)
for more information.

Important Safety Information continued below