See important information below about the risk of hepatitis B virus reactivation.

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Things to know about your hep C treatment

When you start a new treatment, it’s natural to have questions. We’ll provide important information on topics such as how ZEPATIER works, what are common possible side effects, and how to know if your treatment was successful.

How ZEPATIER works for you

ZEPATIER is a breakthrough treatment for hep C that is a combination of 2 different medicines—elbasvir and grazoprevir—in a single pill. These medicines work together to fight the hep C virus. ZEPATIER works by blocking proteins the virus needs to make copies of itself.

Everyone’s story is different. ZEPATIER was studied in people with chronic hep C, including some who had serious liver damage (called cirrhosis). Studies included people:

  • Who were never treated with a hep C medicine

  • Who were previously treated but not cured with medicines called interferon and ribavirin, and sometimes with a hep C protease inhibitor (Incivek®, Olysio®, or Victrelis®)

  • With HIV, or

  • With severe kidney disease

How will I know if my treatment is working?

Everyone is different and may not respond to ZEPATIER in the same way. It's important to continue taking your medicine as directed by your health care provider until you complete your treatment. Your health care provider will test your blood after you complete your treatment to determine if you are cured. Cure means the hep C virus is not detected in the blood when measured 3 months after treatment is completed.

Have more questions about what to expect while taking ZEPATIER? Sign up for the C Ahead™ Patient Support Program to get a discussion worksheet to take with you to your next appointment.

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Appointments and blood tests

During treatment, it's important to keep all of your medical appointments and to have all lab tests done as directed by your health care provider.

Common side effects

ZEPATIER is a clinically proven treatment that can help you turn the page on hep C. Here are some of the most common possible side effects that you should know about when taking ZEPATIER. In clinical studies, common side effects of ZEPATIER included:

  • Feeling tired

  • Headache

  • Nausea

When ZEPATIER was taken with ribavirin, common side effects also included low red blood cell counts (called anemia).

If you experience side effects that bother you or do not go away, speak to your health care provider right away. Do not stop taking ZEPATIER without first talking to your health care team.

Motivation and healthy tips

Sometimes having a goal makes it easier to stay on treatment. Identify what motivates you. It's also important to stick to healthy habits.

 

Sign up today and we’ll send you an e-mail and Tip Sheet that may help you with healthy habits, like eating healthy and exercising. If you’re already enrolled in C Ahead™, your tips are on their way.

SIGN UP TO GET HEALTHY TIPS

Knowing if you are cured

 

Cure means the hep C virus is not detected in the blood when measured 3 months after treatment is completed.

Family planning and pregnancy

 

If you are nursing, pregnant, or trying to get pregnant, tell your health care provider. It is not known if ZEPATIER will harm your unborn baby or pass to your baby through breast milk. If you take ZEPATIER with ribavirin, be sure you read the Medication Guide for ribavirin, especially the important pregnancy, contraception, and infertility information.

Finding more support while
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What is ZEPATIER?

ZEPATIER® (elbasvir and grazoprevir) is a prescription medicine used to treat chronic (long‑lasting) hepatitis C (hep C) genotypes 1 or 4 infection in adults. ZEPATIER may sometimes be given with another medicine called ribavirin.

Important Safety Information

Before starting treatment with ZEPATIER® (elbasvir and grazoprevir), your health care provider will do blood tests to check for hepatitis B virus infection. If you have ever had hepatitis B virus infection, the hepatitis B virus could become active again during or after treatment of hep C virus infection with ZEPATIER. This is called hepatitis B virus reactivation, and it may cause serious liver problems including liver failure and death. Your health care provider will monitor you if you are at risk for hepatitis B virus reactivation during treatment and after you stop taking ZEPATIER.

ZEPATIER is not for people with certain liver problems. Before taking ZEPATIER, tell your health care provider about all of your medical conditions, including if you have ever had hepatitis B virus infection or have liver problems other than hep C. Also tell your health care provider if you have ever taken any medicine for hep C, have HIV, or have had or are waiting for a liver transplant.

If you are nursing, pregnant, or trying to get pregnant, tell your health care provider. It is not known if ZEPATIER® (elbasvir and grazoprevir) will harm your unborn baby or pass to your baby through breast milk. If you take ZEPATIER with ribavirin, be sure you read the Medication Guide for ribavirin, especially the important pregnancy, contraception, and infertility information.

Tell your health care provider about all of the medicines you take. ZEPATIER may affect how other medicines work, and other medicines may affect how ZEPATIER works. Some medicines cannot be taken with ZEPATIER. Your health care provider can tell you if it is safe to take ZEPATIER with other medicines.

ZEPATIER may cause increases in your liver-related blood tests, which could be a sign of serious liver problems. Your health care provider will do blood tests to check your liver before and during treatment with ZEPATIER. Tell your health care provider right away if you get any of the following symptoms or if they get worse during treatment with ZEPATIER: loss of appetite, nausea and vomiting, feeling tired or weak, yellowing of your skin or eyes, or color changes in your stool.

In clinical studies, common side effects of ZEPATIER included: feeling tired, headache, and nausea. When ZEPATIER was taken with ribavirin, common side effects also included low red blood cell counts (called anemia).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

Before taking ZEPATIER® (elbasvir and grazoprevir), please read the accompanying Patient Information, including information about the risk of the hepatitis B virus (HBV) becoming active again in patients who have ever had HBV infection, and discuss it with your doctor. The Prescribing Information also is available.

Questions about ZEPATIER?
Call 844-ZEPATIER (844‑937‑2843)
for more information.




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